Brief Definitive Report
نویسنده
چکیده
Chronic myelocytic leukemia (CML) is associated with the presence o f a Philadelphia (Ph 1) ch romosome in 95% of cases (1). This cytogenetic hallmark is molecularly character ized by the translocation o f the c-abl oncogene f rom chromosome 9 into the breakpoint cluster region (bcr) of chromosome 22 (2-5), and the subsequent transcription o f a chimeric 8.5 kb bcr/c-abl RNA species within leukemic cells (6-8), which represents m R N A for an al tered c-abl protein with associated tyrosine kinase activity (9). PhLnegat ive CML, however, constitute a he te rogeneous group o f prognostically distinct disorders (10). Recently (11), my coworkers and I identified a phi-negative CML patient with a c-abl/bcr rearrangement; however, o ther patients lack this recombinat ion (3). H e re I r epor t on the first Phi-negative CML patient whose leukemic cells exhibit a r ea r rangement in the bcr gene without juxtaposi t ion o f c-abl sequences.
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تاریخ انتشار 2003